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Yes (again) to local NO

A pair of fluorescent indicator-tagged DNA-duplex scaffolds permit assessments of nitric oxide (NO) production on cell surfaces and in intracellular networks. The application of these nanoprobes indicates formations of local NO signals that might conserve cancer cell integrity.

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Fig. 1: Fluorescent DNA-based NO biosensors, the NOckout probes, enable imaging of local NO signals in single cells.


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Correspondence to Roland Malli.

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Eroglu, E., Michel, T., Graier, W.F. et al. Yes (again) to local NO. Nat Chem Biol 16, 606–607 (2020).

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