Circadian rhythms

A tail of CRY selectivity

The discovery of selective modulators of two Cryptochrome isoforms, CRY1 and CRY2, permits a deeper understanding of how circadian clock proteins impact diverse aspects of our daily 24-h rhythms and how this intersects with metabolic pathways relevant to disease.

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Fig. 1: Selective modulation of CRY isoforms.

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Correspondence to Brian D. Zoltowski.

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Lara, J., Zoltowski, B.D. A tail of CRY selectivity. Nat Chem Biol 16, 608–609 (2020). https://doi.org/10.1038/s41589-020-0531-z

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