Flavin doesn’t put all oxygens in one basket

Oxygen activation mechanisms catalyzed by flavin cofactors are established for electron transfer (oxidases) and C4a covalent flavin–oxygen adduct formation (oxygen-inserting monooxygenases). A new paradigm for oxygen insertion involving a flavin-N5-aminoperoxide intermediate has now been discovered in select flavin-dependent monooxygenases.

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Fig. 1: Schematic overview of the flavin mediated O2-reduction process.


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Correspondence to David Leys or Nigel S. Scrutton.

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Leys, D., Scrutton, N.S. Flavin doesn’t put all oxygens in one basket. Nat Chem Biol 16, 485–486 (2020). https://doi.org/10.1038/s41589-020-0523-z

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