ENZYMOLOGY

Flavin doesn’t put all oxygens in one basket

Oxygen activation mechanisms catalyzed by flavin cofactors are established for electron transfer (oxidases) and C4a covalent flavin–oxygen adduct formation (oxygen-inserting monooxygenases). A new paradigm for oxygen insertion involving a flavin-N5-aminoperoxide intermediate has now been discovered in select flavin-dependent monooxygenases.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Schematic overview of the flavin mediated O2-reduction process.

References

  1. 1.

    Romero, E., Gómez Castellanos, J. R., Gadda, G., Fraaije, M. W. & Mattevi, A. Chem. Rev. 118, 1742–1769 (2018).

    CAS  Article  Google Scholar 

  2. 2.

    Matthews, A. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-020-0476-2 (2020).

    Article  PubMed  Google Scholar 

  3. 3.

    Leys, D. & Scrutton, N. S. Curr. Opin. Struct. Biol. 41, 19–26 (2016).

    CAS  Article  Google Scholar 

  4. 4.

    Payne, K. A. P. et al. Nature 522, 497–501 (2015).

    CAS  Article  Google Scholar 

  5. 5.

    Sorigué, D. et al. Science 357, 903–907 (2017).

    Article  Google Scholar 

  6. 6.

    Black, M. J. et al. Nat. Chem. 12, 71–75 (2020).

    Article  Google Scholar 

  7. 7.

    Teufel, R. et al. Nature 503, 552–556 (2013).

    CAS  Article  Google Scholar 

  8. 8.

    Mishanina, T. V. et al. Science 351, 507–510 (2016).

    CAS  Article  Google Scholar 

  9. 9.

    Conrad, K. S., Manahan, C. C. & Crane, B. R. Nat. Chem. Biol. 10, 801–809 (2014).

    CAS  Article  Google Scholar 

  10. 10.

    Kutta, R. J., Archipowa, N. & Scrutton, N. S. Phys. Chem. Chem. Phys. 20, 28767–28776 (2018).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding authors

Correspondence to David Leys or Nigel S. Scrutton.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Leys, D., Scrutton, N.S. Flavin doesn’t put all oxygens in one basket. Nat Chem Biol 16, 485–486 (2020). https://doi.org/10.1038/s41589-020-0523-z

Download citation

Further reading

Search

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing