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DRUG TRANSPORTERS

Hitchhiking into the cell

Nature Chemical Biology volume 16, pages 367–368 (2020)Cite this article

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An Author Correction to this article was published on 08 April 2020

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The mechanisms by which bioactive drugs get into their target cells is a question that has been greatly neglected. A new survey with CRISPR–Cas9 shows the widespread importance of protein transporters called solute carriers (SLCs).

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Fig. 1: Solute carriers are required for drug transport across cellular membranes.

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References

  1. Kell, D. B. & Oliver, S. G. Front. Pharmacol. 5, 231 (2014).

    Article  Google Scholar 

  2. SciAni. How drugs and nutrients get into cells. https://www.youtube.com/watch?v=p36efpGULoM&t=4s (2019).

  3. César-Razquin, A. et al. Front. Pharmacol. 9, 1011 (2018).

    Article  Google Scholar 

  4. César-Razquin, A. et al. Cell 162, 478–487 (2015).

    Article  Google Scholar 

  5. Girardi, E. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-020-0483-3 (2020).

  6. Lanthaler, K. et al. BMC Biol. 9, 70 (2011).

    Article  CAS  Google Scholar 

  7. Winter, G. E. et al. Nat. Chem. Biol. 10, 768–773 (2014).

    Article  CAS  Google Scholar 

  8. Jindal, S., Yang, L., Day, P. J. & Kell, D. B. BMC Microbiol 19, 195 (2019).

    Article  Google Scholar 

  9. Kell, D. B., Swainston, N., Pir, P. & Oliver, S. G. Trends Biotechnol. 33, 237–246 (2015).

    Article  CAS  Google Scholar 

  10. O’Hagan, S., Wright Muelas, M., Day, P. J., Lundberg, E. & Kell, D. B. Cell Syst. 6, 230–244.e1 (2018).

    Article  Google Scholar 

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  1. Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool, UK

    Douglas B. Kell

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  1. Douglas B. Kell
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Correspondence to Douglas B. Kell.

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Kell, D.B. Hitchhiking into the cell. Nat Chem Biol 16, 367–368 (2020). https://doi.org/10.1038/s41589-020-0489-x

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