Retro-2 is a drug that protects cells against bacterial and plant toxins by arresting their trafficking in endosomes. New data show that the target for Retro-2 is surprisingly not within the endosomal system, but on the endoplasmic reticulum.
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Farhan, H. Rendezvous of Retro-2 at the ER. Nat Chem Biol 16, 229–230 (2020). https://doi.org/10.1038/s41589-020-0475-3