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Rendezvous of Retro-2 at the ER

Retro-2 is a drug that protects cells against bacterial and plant toxins by arresting their trafficking in endosomes. New data show that the target for Retro-2 is surprisingly not within the endosomal system, but on the endoplasmic reticulum.

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Fig. 1: The newly identified mode of action of Retro2.


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Correspondence to Hesso Farhan.

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Farhan, H. Rendezvous of Retro-2 at the ER. Nat Chem Biol 16, 229–230 (2020).

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