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Leveraging bias to your advantage

Characterization of biased receptor signaling has ushered in opportunities for unprecedented control of G-protein-coupled receptors. Elucidation of distinct M1 muscarinic acetylcholine receptor signaling pathways and development of biased ligands may offer novel and safer Alzheimer’s disease therapeutics.

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Fig. 1: Probing the signaling pathway(s) that mediate the effects of M1 mAChR modulation.


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Correspondence to P. Jeffrey Conn.

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Moran, S.P., Conn, P.J. Leveraging bias to your advantage. Nat Chem Biol 16, 226–227 (2020).

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