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Desperately seeking sortase

Directed evolution on the yeast cell surface enables the discovery of sortase variants with altered specificity capable of modifying Aβ peptides under physiologically relevant conditions.

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Fig. 1: Directed evolution of peptide ligase activity on the yeast surface.


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Correspondence to James A. Van Deventer.

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Van Deventer, J.A. Desperately seeking sortase. Nat Chem Biol 17, 235–236 (2021).

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