Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


BETting against wound healing

A chemical screen identifies BET bromodomain inhibitors as inducers of an activated skin keratinocyte state that promotes the wound-healing capabilities of these cells. The study implicates epigenetic modifiers as potential targets for non-healing, chronic wounds.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: BET inhibitors reprogram skin keratinocytes to enhance wound healing.


  1. 1.

    Biggs, L. C., Kim, C. S., Miroshnikova, Y. A. & Wickström, S. A. J. Invest. Dermatol. 140, 284–290 (2020).

    CAS  Article  Google Scholar 

  2. 2.

    Eming, S. A., Martin, P. & Tomic-Canic, M. Sci. Transl. Med. 6, 265sr6 (2014).

    Article  Google Scholar 

  3. 3.

    Lewis, C. J., Stevenson, A., Fear, M. W. & Wood, F. M. Wound Repair Regen. 28, 710–718 (2020).

    Article  Google Scholar 

  4. 4.

    Schutzius, G. et al. Nat. Chem. Biol. (2020).

  5. 5.

    Pastar, I. et al. Adv. Wound Care (New Rochelle) 3, 445–464 (2014).

    Article  Google Scholar 

  6. 6.

    Muller, S., Filippakopoulos, P. & Knapp, S. Expert Rev. Mol. Med. 13, e29 (2011).

    Article  Google Scholar 

  7. 7.

    Pérez-Salvia, M. & Esteller, M. Epigenetics 12, 323–339 (2017).

    Article  Google Scholar 

  8. 8.

    Pervaiz, M., Mishra, P. & Günther, S. Chem. Rec. 18, 1808–1817 (2018).

    CAS  Article  Google Scholar 

  9. 9.

    Miroshnikova, Y. A., Cohen, I., Ezhkova, E. & Wickström, S. A. Curr. Opin. Genet. Dev. 55, 46–51 (2019).

    CAS  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Sara A. Wickström.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Ylivinkka, I., Wickström, S.A. BETting against wound healing. Nat Chem Biol 17, 233–235 (2021).

Download citation


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing