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EPIGENETIC REGULATION

BETting against wound healing

A chemical screen identifies BET bromodomain inhibitors as inducers of an activated skin keratinocyte state that promotes the wound-healing capabilities of these cells. The study implicates epigenetic modifiers as potential targets for non-healing, chronic wounds.

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Fig. 1: BET inhibitors reprogram skin keratinocytes to enhance wound healing.

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Correspondence to Sara A. Wickström.

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Ylivinkka, I., Wickström, S.A. BETting against wound healing. Nat Chem Biol 17, 233–235 (2021). https://doi.org/10.1038/s41589-020-00709-y

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