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EPIGENETIC REGULATION

BETting against wound healing

Nature Chemical Biology volume 17, pages 233–235 (2021)Cite this article

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A chemical screen identifies BET bromodomain inhibitors as inducers of an activated skin keratinocyte state that promotes the wound-healing capabilities of these cells. The study implicates epigenetic modifiers as potential targets for non-healing, chronic wounds.

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Fig. 1: BET inhibitors reprogram skin keratinocytes to enhance wound healing.

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Authors and Affiliations

  1. Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland

    Irene Ylivinkka & Sara A. Wickström

  2. Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland

    Irene Ylivinkka & Sara A. Wickström

  3. Stem Cells and Metabolism Resesarch Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

    Irene Ylivinkka & Sara A. Wickström

Authors
  1. Irene Ylivinkka
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  2. Sara A. Wickström
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Correspondence to Sara A. Wickström.

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The authors declare no competing interests.

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Ylivinkka, I., Wickström, S.A. BETting against wound healing. Nat Chem Biol 17, 233–235 (2021). https://doi.org/10.1038/s41589-020-00709-y

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