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Bringing distant DNA together

Yin Yang 1 (YY1) is a transcription factor involved in gene regulation. A recent study has revealed G-quadruplex structures as novel binding targets of YY1, and their interactions regulate DNA looping and gene expression.

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Fig. 1: Novel interaction of YY1 and G4 mediates DNA looping and gene expression.


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Correspondence to Chun Kit Kwok.

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Zhao, H., Kwok, C.K. Bringing distant DNA together. Nat Chem Biol 17, 125–126 (2021).

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