Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Bringing distant DNA together

Yin Yang 1 (YY1) is a transcription factor involved in gene regulation. A recent study has revealed G-quadruplex structures as novel binding targets of YY1, and their interactions regulate DNA looping and gene expression.

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: Novel interaction of YY1 and G4 mediates DNA looping and gene expression.


  1. Di Antonio, M. et al. Nat. Chem. 12, 832–837 (2020).

    Article  Google Scholar 

  2. Varshney, D., Spiegel, J., Zyner, K., Tannahill, D. & Balasubramanian, S. Nat. Rev. Mol. Cell Biol. 21, 459–474 (2020).

    CAS  Article  Google Scholar 

  3. Williams, P., Li, L., Dong, X. & Wang, Y. J. Am. Chem. Soc. 139, 12426–12429 (2017).

    CAS  Article  Google Scholar 

  4. Li., L. et al. Nat. Chem. Biol. (2020).

  5. Atchison, M. L. Front. Immunol. 5, 45 (2014).

    Article  Google Scholar 

  6. Hyde-DeRuyscher, R. P., Jennings, E. & Shenk, T. Nucleic Acids Res. 23, 4457–4465 (1995).

    CAS  Article  Google Scholar 

  7. Houbaviy, H. B., Usheva, A., Shenk, T. & Burley, S. K. Proc. Natl. Acad. Sci. USA 93, 13577–13582 (1996).

    CAS  Article  Google Scholar 

  8. Weintraub, A. S. et al. Cell 171, 1573–1588.e28 (2017).

    CAS  Article  Google Scholar 

  9. Deng, Z., Cao, P., Wan, M. M. & Sui, G. Transcription 1, 81–84 (2010).

    Article  Google Scholar 

  10. Gordon, S., Akopyan, G., Garban, H. & Bonavida, B. Oncogene 25, 1125–1142 (2006).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Chun Kit Kwok.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Zhao, H., Kwok, C.K. Bringing distant DNA together. Nat Chem Biol 17, 125–126 (2021).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing