The site-specific monoubiquitination of FANCD2 is crucial for the Fanconi anemia DNA repair pathway and tumor suppression. This modification is mediated by the E2 enzyme UBE2T and the E3 ligase FANCL through a novel allosteric mechanism.
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Sato, K., Knipscheer, P. Rewiring E2 enzymes. Nat Chem Biol 16, 227–229 (2020). https://doi.org/10.1038/s41589-019-0454-8