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LIPID BIOLOGY

Going through a phase

Genetic screens uncover a bioactivation pathway for Lasonolide A involving enrichment in lipid droplets and cleavage into a cytotoxic, soluble metabolite by a lipid droplet-associated serine hydrolase. These findings identify enzymatically regulated phase partitioning as a drug activation mechanism.

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Fig. 1: Enzymatic processing by the ER and lipid droplet localized hydrolase LDAH controls LasA phase partitioning and cytotoxicity.

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Correspondence to James A. Olzmann.

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Li, Z., Morris, S.N.S. & Olzmann, J.A. Going through a phase. Nat Chem Biol 16, 111–112 (2020). https://doi.org/10.1038/s41589-019-0448-6

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