SYNTHETIC BIOLOGY

Mammalian signaling circuits from bacterial parts

The ability to engineer synthetic signaling networks has proven challenging for synthetic biology. A breakthrough design strategy shows that bacterial two-component-system-derived parts can be grafted into mammalian cells to create programmable phosphorylation circuitry.

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Fig. 1: Harnessing molecular parts from a bacterial two-component system to engineer signaling pathways in mammalian cells.

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Correspondence to Caleb J. Bashor.

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Yang, X., Her, J. & Bashor, C.J. Mammalian signaling circuits from bacterial parts. Nat Chem Biol 16, 110–111 (2020). https://doi.org/10.1038/s41589-019-0436-x

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