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Processing for destruction

Phenotypic screening is an engine of discovery for bioactive small molecules and can unravel novel mechanisms and pathways controlling cellular physiology. A recent study reveals the CPSF complex as a pharmacologically tractable target of JTE-607 and context-specific cancer dependency.

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Fig. 1: Mechanism of action of JTE-607 anticancer effects.


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Correspondence to Michael A. Erb.

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Erb, M.A. Processing for destruction. Nat Chem Biol 16, 3–4 (2020).

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