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TARGETED PROTEIN DEGRADATION

Molecular glue concept solidifies

Molecular-glue-mediated proximity-induced degradation now allows unprecedented therapeutic targeting of previously undruggable proteins. Structures showing how aryl-sulfonamides mediate recruitment of the splicing factor RBM39 to the E3 CRL4DCAF15 broaden the mechanistic principles by which molecular glues target ubiquitylation.

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Fig. 1: Mechanism of molecular glue induced substrate recruitment to CRL4.

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Correspondence to Brenda A. Schulman.

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Baek, K., Schulman, B.A. Molecular glue concept solidifies. Nat Chem Biol 16, 2–3 (2020). https://doi.org/10.1038/s41589-019-0414-3

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