Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

NEUROBIOLOGY

Axonal dispatch of iron in neuronal signaling

Nature Chemical Biology volume 15, pages 1135–1136 (2019)Cite this article

Subjects

The regulation of brain iron homeostasis, previously thought to be cell autonomous and modulated by local factors in the interstitial fluid, is reported by Wang et al. to be strongly influenced by axonal transport of iron in an activity-dependent and unidirectional manner between functionally associated regions. The supply of iron from the ventral hippocampus to the middle prefrontal cortex subserved an anxiolytic phenotype and mediated the neuropharmacological actions of diazepam and lithium chloride in rodent models.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Schematic illustration of neuronal activity-dependent iron transport and its psychiatric relevance.

References

  1. Hare, D., Ayton, S., Bush, A. & Lei, P. Front. Aging Neurosci. 5, 34 (2013).

    Article  Google Scholar 

  2. Barnham, K. J. & Bush, A. I. Chem. Soc. Rev. 43, 6727–6749 (2014).

    Article  CAS  Google Scholar 

  3. Wang, Z. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-019-0371-x (2019).

  4. Ayton, S. et al. Mol. Psychiatry https://doi.org/10.1038/s41380-019-0375-7 (2019).

  5. Lei, P. et al. Nat. Med. 18, 291–295 (2012).

    Article  CAS  Google Scholar 

  6. Kim, J. & Wessling-Resnick, M. J. Nutr. Biochem. 25, 1101–1107 (2014).

    Article  CAS  Google Scholar 

  7. Lei, P. et al. Mol. Psychiatry 22, 396–406 (2017).

    Article  CAS  Google Scholar 

  8. Waldmeier, P. C., Buchle, A. M. & Steulet, A. F. Biochem. Pharmacol. 45, 2417–2424 (1993).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurology and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, P.R. China

    Peng Lei

  2. Melbourne Dementia Research Centre, Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Victoria, Australia

    Peng Lei, Scott Ayton & Ashley I. Bush

Authors
  1. Peng Lei
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Scott Ayton
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ashley I. Bush
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Peng Lei or Ashley I. Bush.

Ethics declarations

Competing interests

A.I.B. is a shareholder in Prana Biotechnology Ltd., Cogstate Ltd., Brighton Biotech LLC, Grunbiotics Pty Ltd., Eucalyptus Pty Ltd., and Mesoblast Ltd. He is a paid consultant for, and has a profit share interest in, Collaborative Medicinal Development Pty Ltd.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lei, P., Ayton, S. & Bush, A.I. Axonal dispatch of iron in neuronal signaling. Nat Chem Biol 15, 1135–1136 (2019). https://doi.org/10.1038/s41589-019-0394-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41589-019-0394-3

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing