CO-TRANSCRIPTIONAL FOLDING

A newborn RNA switches its fate

Riboswitches enable microbes to rapidly respond to changing levels of metabolites. A high-throughput platform reveals how RNA structural transitions kinetically compete during transcription in a new mechanism for riboswitch function.

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Fig. 1: The ZMP riboswitch makes a co-transcriptional decision.

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Correspondence to Sarah A. Woodson.

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Rodgers, M.L., Hao, Y. & Woodson, S.A. A newborn RNA switches its fate. Nat Chem Biol 15, 1031–1032 (2019). https://doi.org/10.1038/s41589-019-0391-6

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