A newborn RNA switches its fate

Riboswitches enable microbes to rapidly respond to changing levels of metabolites. A high-throughput platform reveals how RNA structural transitions kinetically compete during transcription in a new mechanism for riboswitch function.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: The ZMP riboswitch makes a co-transcriptional decision.


  1. 1.

    Strobel, E.J., Cheng, L., Berman, K.E., Carlson, P.D. & Lucks, J.B. Nat. Chem. Biol. (2019).

  2. 2.

    Jones, C. P. & Ferré-D’Amaré, A. R. Annu. Rev. Biophys. 46, 1–27 (2016).

  3. 3.

    Kim, P. B., Nelson, J. W. & Breaker, R. R. Mol. Cell 57, 317–328 (2015).

  4. 4.

    Wickiser, K. J., Winkler, W. C., Breaker, R. R. & Crothers, D. M. Mol. Cell 18, 49–60 (2005).

  5. 5.

    Frieda, K. L. & Block, S. M. Science 338, 397–400 (2012).

  6. 6.

    Strobel, E. J., Watters, K. E., Nedialkov, Y., Artsimovitch, I. & Lucks, J. B. Nucleic Acids Res. 45, e109 (2017).

  7. 7.

    Wilkinson, K. A., Merino, E. J. & Weeks, K. M. Nat. Protoc. 1, 1610–1616 (2006).

  8. 8.

    Lai, D., Proctor, J. R. & Meyer, I. M. RNA 19, 1461–1473 (2013).

  9. 9.

    Hua, B., Panja, S., Wang, Y., Woodson, S. & Ha, T. J. Am. Chem. Soc. 140, 10067–10070 (2018).

Download references

Author information



Corresponding author

Correspondence to Sarah A. Woodson.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Rodgers, M.L., Hao, Y. & Woodson, S.A. A newborn RNA switches its fate. Nat Chem Biol 15, 1031–1032 (2019).

Download citation

Further reading