Motor proteins

The tail wags the motor

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Cytoplasmic dynein is a complex molecular motor that steps along microtubules. Advanced biophysical measurements reveal a surprising role for the dynein tail domain in the allosteric control of dynein’s mechanochemistry within assemblies composed of multiple dynein motors.

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Fig. 1: Scheme of intermolecular allosteric regulation within multi-motor dynein–dynactin–cargo adaptor assemblies.


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Correspondence to Richard J. McKenney.

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