Cytoplasmic dynein is a complex molecular motor that steps along microtubules. Advanced biophysical measurements reveal a surprising role for the dynein tail domain in the allosteric control of dynein’s mechanochemistry within assemblies composed of multiple dynein motors.
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References
Reck-Peterson, S. L., Redwine, W. B., Vale, R. D. & Carter, A. P. Nat. Rev. Mol. Cell Biol. 19, 382–398 (2018).
McKenney, R. J., Huynh, W., Tanenbaum, M. E., Bhabha, G. & Vale, R. D. Science 345, 337–341 (2014).
Schlager, M. A., Hoang, H. T., Urnavicius, L., Bullock, S. L. & Carter, A. P. EMBO J. 33, 1855–1868 (2014).
Urnavicius, L. et al. Nature 554, 202–206 (2018).
Grotjahn, D. A. et al. Nat. Struct. Mol. Biol. 25, 203–207 (2018).
Elshenawy, M. M. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-019-0352-0 (2019).
Schlager, M. A. et al. Cell Rep. 8, 1248–1256 (2014).
Cianfrocco, M. A., DeSantis, M. E., Leschziner, A. E. & Reck-Peterson, S. L. Annu. Rev. Cell Dev. Biol. 31, 83–108 (2015).
Marzo, M. G. et al. eLife 8, e47246 (2019).
Hoang, H. T., Schlager, M. A., Carter, A. P. & Bullock, S. L. Proc. Natl Acad. Sci. USA 114, E1597–E1606 (2017).
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McKenney, R.J. The tail wags the motor. Nat Chem Biol 15, 1033–1034 (2019). https://doi.org/10.1038/s41589-019-0367-6
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DOI: https://doi.org/10.1038/s41589-019-0367-6