RNA MODIFICATIONS

Site-specific m6A editing

The N6-methyladenosine modification on RNA affects almost all steps of RNA metabolism. A new approach, using the CRISPR-based technology to modulate m6A level in mRNA, enables direct functional interrogation of site-specific m6A.

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Fig. 1: Depiction of Site-specific m6A editing.

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Correspondence to Chuan He.

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C.H. is a scientific founder of Accent Therapeutics and a member of its scientific advisory board.

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Wei, J., He, C. Site-specific m6A editing. Nat Chem Biol 15, 848–849 (2019). https://doi.org/10.1038/s41589-019-0349-8

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