Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Site-specific m6A editing

The N6-methyladenosine modification on RNA affects almost all steps of RNA metabolism. A new approach, using the CRISPR-based technology to modulate m6A level in mRNA, enables direct functional interrogation of site-specific m6A.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: Depiction of Site-specific m6A editing.


  1. Liu, X.-M. et al. Nat. Chem. Biol. (2019).

  2. Dominissini, D. et al. Nature 485, 201–206 (2012).

    Article  CAS  Google Scholar 

  3. Linder, B. et al. Nat. Methods 12, 767–772 (2015).

    Article  CAS  Google Scholar 

  4. Rauch, S., He, C. & Dickinson, B. C. J. Am. Chem. Soc. 140, 11974–11981 (2018).

    Article  CAS  Google Scholar 

  5. Shi, H., Wei, J. & He, C. Mol. Cell 74, 640–645 (2019).

    Article  CAS  Google Scholar 

  6. Rauch, S. et al. Cell 178, 122–134.e12 (2019).

    Article  CAS  Google Scholar 

  7. Mauer, J. et al. Nature 541, 371–375 (2017).

    Article  CAS  Google Scholar 

  8. Mauer, J. et al. Nat. Chem. Biol. 15, 340–347 (2019).

    Article  CAS  Google Scholar 

  9. Wei, J. et al. Mol. Cell 71, 973–985.e5 (2018).

    Article  CAS  Google Scholar 

  10. Akichika., S. et al. Science 363, eaav0080 (2019).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Chuan He.

Ethics declarations

Competing interests

C.H. is a scientific founder of Accent Therapeutics and a member of its scientific advisory board.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Wei, J., He, C. Site-specific m6A editing. Nat Chem Biol 15, 848–849 (2019).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing