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RNA MODIFICATIONS

Site-specific m6A editing

The N6-methyladenosine modification on RNA affects almost all steps of RNA metabolism. A new approach, using the CRISPR-based technology to modulate m6A level in mRNA, enables direct functional interrogation of site-specific m6A.

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Fig. 1: Depiction of Site-specific m6A editing.

References

  1. Liu, X.-M. et al. Nat. Chem. Biol. https://doi.org/10.1038/10.1038/s41589-019-0327-1 (2019).

  2. Dominissini, D. et al. Nature 485, 201–206 (2012).

    Article  CAS  Google Scholar 

  3. Linder, B. et al. Nat. Methods 12, 767–772 (2015).

    Article  CAS  Google Scholar 

  4. Rauch, S., He, C. & Dickinson, B. C. J. Am. Chem. Soc. 140, 11974–11981 (2018).

    Article  CAS  Google Scholar 

  5. Shi, H., Wei, J. & He, C. Mol. Cell 74, 640–645 (2019).

    Article  CAS  Google Scholar 

  6. Rauch, S. et al. Cell 178, 122–134.e12 (2019).

    Article  CAS  Google Scholar 

  7. Mauer, J. et al. Nature 541, 371–375 (2017).

    Article  CAS  Google Scholar 

  8. Mauer, J. et al. Nat. Chem. Biol. 15, 340–347 (2019).

    Article  CAS  Google Scholar 

  9. Wei, J. et al. Mol. Cell 71, 973–985.e5 (2018).

    Article  CAS  Google Scholar 

  10. Akichika., S. et al. Science 363, eaav0080 (2019).

    Article  Google Scholar 

Download references

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Correspondence to Chuan He.

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Competing interests

C.H. is a scientific founder of Accent Therapeutics and a member of its scientific advisory board.

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Wei, J., He, C. Site-specific m6A editing. Nat Chem Biol 15, 848–849 (2019). https://doi.org/10.1038/s41589-019-0349-8

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  • DOI: https://doi.org/10.1038/s41589-019-0349-8

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