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An unusual terpene nucleoside, 1-TbAd, made by pathogenic mycobacteria acts as an antacid to block mycobacterial degradation in host cell vacuoles. The antacid activity acts to reduce acidity by neutralizing the pH of these degradative cell organelles.

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Fig. 1: The pathogenic bacterium Mycobacterium tuberculosis (Mtb, in green) is engulfed by macrophages inside the lung.


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Correspondence to Priscille Brodin.

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Brodin, P., Hoffmann, E. T(oo)bAd. Nat Chem Biol 15, 849–850 (2019).

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