Polar-opposite fates

Asymmetric cell division, which generates daughter cells with distinct characteristics, is a mechanism for creating complex systems through cellular differentiation. Two studies in this issue develop synthetic platforms that program spatial localization of genetic material or signaling molecules to enable asymmetric cell division in Escherichia coli.

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Fig. 1: Cellular differentiation through asymmetric cell division.


  1. 1.

    Mushnikov, N.V., Fomicheva, A., Gomelsky, M. & Bowman, G.R. Nat. Chem. Biol. (2019).

  2. 2.

    Molinari, S. et al. Nat. Chem. Biol. (2019).

  3. 3.

    Inaba, M. & Yamashita, Y. M. Cell Stem Cell 11, 461–469 (2012).

  4. 4.

    Gardner, T. S., Cantor, C. R. & Collins, J. J. Nature 403, 339–342 (2000).

  5. 5.

    Bi, E. F. & Lutkenhaus, J. Nature 354, 161–164 (1991).

  6. 6.

    Simon, J.R., Eghtesadi, S.A., Dzuricky, M., You, L. & Chilkoti, A. Mol. Cell (2019).

  7. 7.

    Myhrvold, C., Kotula, J. W., Hicks, W. M., Conway, N. J. & Silver, P. A. Nat. Commun. 6, 10039 (2015).

  8. 8.

    Cao, Y. et al. Cell 165, 620–630 (2016).

  9. 9.

    Maharbiz, M. M. Trends Cell Biol. 22, 617–623 (2012).

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Correspondence to Lingchong You.

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