The limited availability of small-molecule ligands for E3 ubiquitin ligases stymies the development of next-generation degraders. Two recent papers report the identification of novel, covalent and PROTAC-compatible ligands that hijack the previously untargeted ligases RNF114 and DCAF16.
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Brand, M., Winter, G.E. Stick it to E3s. Nat Chem Biol 15, 655–656 (2019). https://doi.org/10.1038/s41589-019-0312-8
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DOI: https://doi.org/10.1038/s41589-019-0312-8
