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Autophagy

Lipids lead the way

Autophagy is a ‘self-eating’ recycling process that maintains cellular homeostasis. Autogramins were identified as small-molecule autophagy inhibitors that target the cholesterol transport protein GRAMD1A, revealing a role for cholesterol in autophagosome biogenesis.

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Fig. 1: Inhibition of GRAMD1A by autogramins prevents autophagosome formation.

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Correspondence to Leslie N. Aldrich.

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Aldrich, L.N. Lipids lead the way. Nat Chem Biol 15, 653–654 (2019). https://doi.org/10.1038/s41589-019-0309-3

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