Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Autophagy

Lipids lead the way

Nature Chemical Biology volume 15, pages 653–654 (2019)Cite this article

Subjects

Autophagy is a ‘self-eating’ recycling process that maintains cellular homeostasis. Autogramins were identified as small-molecule autophagy inhibitors that target the cholesterol transport protein GRAMD1A, revealing a role for cholesterol in autophagosome biogenesis.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Inhibition of GRAMD1A by autogramins prevents autophagosome formation.

References

  1. Dikic, I. & Elazar, Z. Nat. Rev. Mol. Cell Biol. 19, 349–364 (2018).

    Article  CAS  Google Scholar 

  2. Laraia, L. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-019-0307-5 (2019).

  3. Egan, D. F. et al. Mol. Cell 59, 285–297 (2015).

    Article  CAS  Google Scholar 

  4. Petherick, K. J. et al. J. Biol. Chem. 290, 11376–11383 (2015).

    Article  CAS  Google Scholar 

  5. Ronan, B. et al. Nat. Chem. Biol. 10, 1013–1019 (2014).

    Article  CAS  Google Scholar 

  6. Dowdle, W. E. et al. Nat. Cell Biol. 16, 1069–1079 (2014).

    Article  CAS  Google Scholar 

  7. Bago, R. et al. Biochem. J. 463, 413–427 (2014).

    Article  CAS  Google Scholar 

  8. Wang, B. et al. Mol. Cell 74, 742–757.e8 (2019).

    Article  CAS  Google Scholar 

  9. Sandhu, J. et al. Cell 175, 514–529.e20 (2018).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry, University of Illinois at Chicago, Chicago, IL, USA

    Leslie N. Aldrich

Authors
  1. Leslie N. Aldrich
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Leslie N. Aldrich.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Aldrich, L.N. Lipids lead the way. Nat Chem Biol 15, 653–654 (2019). https://doi.org/10.1038/s41589-019-0309-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41589-019-0309-3

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research