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Choosing your druggability battle

The advent of PROTACs that degrade the entire protein target rather than simply inhibiting it bring druggable yet apparently non-functional binding sites into play for medicinal chemists to do their work.

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Fig. 1: SMARCA2 presents two domains: the druggable bromodomain and the functional ATPase domain.


  1. Filippakopoulos, P. et al. Nature 468, 1067–1073 (2010).

    Article  CAS  Google Scholar 

  2. Smith, S. G. & Zhou, M.-M. ACS Chem. Biol. 11, 598–608 (2016).

    Article  CAS  Google Scholar 

  3. Kadoch, C. & Crabtree, G. R. Sci. Adv. 1, e1500447 (2015).

    Article  Google Scholar 

  4. Vangamudi, B. et al. Cancer Res. 75, 3865–3878 (2015).

    Article  CAS  Google Scholar 

  5. Papillon, J. P. N. et al. J. Med. Chem. 61, 10155–10172 (2018).

    Article  CAS  Google Scholar 

  6. Farnaby, W. et al. Nat. Chem. Biol. (2019).

  7. Toure, M. & Crews, C. M. Angew. Chem. Int. Edn Engl. 55, 1966–1973 (2016).

    Article  CAS  Google Scholar 

  8. Zengerle, M., Chan, K. H. & Ciulli, A. ACS Chem. Biol. 10, 1770–1777 (2015).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Dafydd Owen.

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Dafydd Owen is a shareholder in Pfizer Inc.

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Owen, D. Choosing your druggability battle. Nat Chem Biol 15, 652–653 (2019).

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