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Choosing your druggability battle

The advent of PROTACs that degrade the entire protein target rather than simply inhibiting it bring druggable yet apparently non-functional binding sites into play for medicinal chemists to do their work.

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Fig. 1: SMARCA2 presents two domains: the druggable bromodomain and the functional ATPase domain.


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Correspondence to Dafydd Owen.

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Dafydd Owen is a shareholder in Pfizer Inc.

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Owen, D. Choosing your druggability battle. Nat Chem Biol 15, 652–653 (2019).

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