Chemical probes that irreversibly inhibit protein function may be used across species to discover proteins. Combining phenotypic screening and activity-based protein profiling, a new study uncovers a discrete lipid signaling pathway regulating lifespan in the worm Caenorhabditis elegans.
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Gertsch, J. Scaffold and organism hopping with chemical probes. Nat Chem Biol 15, 428–429 (2019). https://doi.org/10.1038/s41589-019-0275-9
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DOI: https://doi.org/10.1038/s41589-019-0275-9
