Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


ARGuing for a new kinase class

Arginine protein kinases regulate bacterial signaling cascades through phosphorylation of key arginine residues. Crystal structures of the kinase McsB provide the first glimpse of how these unusual enzymes recognize their protein substrates and are allosterically regulated.

This is a preview of subscription content

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: Structure of activated McsB dimer.


  1. 1.

    Pawson, T. & Scott, J. D. Science 278, 2075–2080 (1997).

    CAS  Article  Google Scholar 

  2. 2.

    Knighton, D. R. et al. Science 253, 407–414 (1991).

    CAS  Article  Google Scholar 

  3. 3.

    Trentini, D. B. et al. Nature 539, 48–53 (2016).

    CAS  Article  Google Scholar 

  4. 4.

    Elsholz, A. K. et al. Proc. Natl Acad. Sci. USA 109, 7451–7456 (2012).

    CAS  Article  Google Scholar 

  5. 5.

    Fuhrmann, J. et al. Science 324, 1323–1327 (2009).

    CAS  Article  Google Scholar 

  6. 6.

    Suskiewicz, M.J. et al. Nat. Chem. Biol. (2019).

    Article  Google Scholar 

  7. 7.

    Adams, J. A. Chem. Rev. 101, 2271–2290 (2001).

    CAS  Article  Google Scholar 

  8. 8.

    Hammarén, H. M., Virtanen, A. T. & Silvennoinen, O. Biosci. Rep. 36, e00282 (2015).

    Article  Google Scholar 

  9. 9.

    Ellington, W. R. Annu. Rev. Physiol. 63, 289–325 (2001).

    CAS  Article  Google Scholar 

  10. 10.

    Yousef, M. S., Fabiola, F., Gattis, J. L., Somasundaram, T. & Chapman, M. S. Acta Crystallogr. D Biol. Crystallogr. 58, 2009–2017 (2002).

    Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Titus J. Boggon.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Boggon, T.J. ARGuing for a new kinase class. Nat Chem Biol 15, 431–432 (2019).

Download citation


Quick links