ARGuing for a new kinase class

Arginine protein kinases regulate bacterial signaling cascades through phosphorylation of key arginine residues. Crystal structures of the kinase McsB provide the first glimpse of how these unusual enzymes recognize their protein substrates and are allosterically regulated.

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Fig. 1: Structure of activated McsB dimer.


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Correspondence to Titus J. Boggon.

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Boggon, T.J. ARGuing for a new kinase class. Nat Chem Biol 15, 431–432 (2019).

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