Arginine protein kinases regulate bacterial signaling cascades through phosphorylation of key arginine residues. Crystal structures of the kinase McsB provide the first glimpse of how these unusual enzymes recognize their protein substrates and are allosterically regulated.
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References
Pawson, T. & Scott, J. D. Science 278, 2075–2080 (1997).
Knighton, D. R. et al. Science 253, 407–414 (1991).
Trentini, D. B. et al. Nature 539, 48–53 (2016).
Elsholz, A. K. et al. Proc. Natl Acad. Sci. USA 109, 7451–7456 (2012).
Fuhrmann, J. et al. Science 324, 1323–1327 (2009).
Suskiewicz, M.J. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-019-0265-y (2019).
Adams, J. A. Chem. Rev. 101, 2271–2290 (2001).
Hammarén, H. M., Virtanen, A. T. & Silvennoinen, O. Biosci. Rep. 36, e00282 (2015).
Ellington, W. R. Annu. Rev. Physiol. 63, 289–325 (2001).
Yousef, M. S., Fabiola, F., Gattis, J. L., Somasundaram, T. & Chapman, M. S. Acta Crystallogr. D Biol. Crystallogr. 58, 2009–2017 (2002).
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Boggon, T.J. ARGuing for a new kinase class. Nat Chem Biol 15, 431–432 (2019). https://doi.org/10.1038/s41589-019-0272-z
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DOI: https://doi.org/10.1038/s41589-019-0272-z