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Harvesting Moco

The molybdenum cofactor (Moco) is a fragile prosthetic group essential for most organisms. Nematodes are now capable of extracting Moco from their bacterial diet to mediate detoxification of sulfite.

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Fig. 1: Interkingdom transfer of the prosthetic group molybdenum cofactor (Moco) and its precursor cPMP from the bacterium E. coli to the nematode C. elegans.


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Correspondence to Ralf R. Mendel.

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Mendel, R.R., Hercher, T.W. Harvesting Moco. Nat Chem Biol 15, 429–430 (2019).

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