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Affinity selection and sequencing

Powerful combinatorial peptide library methods allow the discovery of peptide leads from diverse libraries. A new platform based on tandem mass spectrometry peptide sequencing coupled with high-performance size-exclusion chromatography enables identification of high-affinity peptidic ligands from focused libraries.

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Fig. 1: Affinity selection–mass spectrometry (AS–MS) method for identifying high-affinity peptide ligands.


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Correspondence to Kit S. Lam.

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Lam, K.S. Affinity selection and sequencing. Nat Chem Biol 15, 320–321 (2019).

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