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RNA MODIFICATIONS

New roles for old RNA cap flavors

The N6-methyladenosine modification next to the 5′ RNA cap has dynamic regulatory functions. Recent findings show that this modification regulates the splicing and translational activity of different classes of RNAs.

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Fig. 1: Structure of the 5′ cap on RNAs synthesized by RNA Pol II.

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Correspondence to Richard A. Padgett.

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Padgett, R.A. New roles for old RNA cap flavors. Nat Chem Biol 15, 317–318 (2019). https://doi.org/10.1038/s41589-019-0252-3

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