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ION CHANNELS

A flexible filter maintains a tight grip

Nature Chemical Biologyvolume 15pages319320 (2019) | Download Citation

Potassium channels allow the passage of potassium ions across membranes at rates approaching the diffusion limit while maintaining exquisite selectivity between ion species. Single-molecule studies now reveal that the selectivity filter of these proteins transitions between different conformations.

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References

  1. 1.

    Zhou, Y., Morais-Cabral, J. H., Kaufman, A. & MacKinnon, R. Nature 414, 43–48 (2001).

  2. 2.

    Wang, S., Lee, S.-J., Maksaev, G., Fang, C. & Nichols, C. G. Nat. Chem. Biol. https://doi.org/10.1038/s41589-019-0240-7 (2019).

  3. 3.

    Zhou, Y. & MacKinnon, R. J. Mol. Biol. 333, 965–975 (2003).

  4. 4.

    Roux, B. Essays Biochem. 61, 201–209 (2017).

  5. 5.

    Lenaeus, M. J., Burdette, D., Wagner, T., Focia, P. J. & Gross, A. Biochemistry 53, 5365–5373 (2014).

  6. 6.

    Derebe, M. G. et al. Proc. Natl Acad. Sci. USA 108, 598–602 (2011).

  7. 7.

    Lockless, S. W. J. Gen. Physiol. 146, 3–13 (2015).

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Author information

Affiliations

  1. Department of Biochemistry and Molecular Biology, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA

    • Adrian Gross

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The author declares no competing interests.

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Correspondence to Adrian Gross.

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https://doi.org/10.1038/s41589-019-0248-z

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