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CELL DEATH

Tightening a deadly pore former

A small molecule was identified that binds to a unique site on the pro-apoptotic protein BAX, stabilizing the protein structure allosterically and preventing the conformational activation to a pore former by BH3 proteins.

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Fig. 1: A small molecule protein stabilizer prevents proapoptotic BAX pore formation in the mitochondrial membrane.

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Correspondence to Jialing Lin.

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Lin, J. Tightening a deadly pore former. Nat Chem Biol 15, 316–317 (2019). https://doi.org/10.1038/s41589-019-0235-4

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