A small molecule was identified that binds to a unique site on the pro-apoptotic protein BAX, stabilizing the protein structure allosterically and preventing the conformational activation to a pore former by BH3 proteins.
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Lin, J. Tightening a deadly pore former. Nat Chem Biol 15, 316–317 (2019). https://doi.org/10.1038/s41589-019-0235-4
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DOI: https://doi.org/10.1038/s41589-019-0235-4
