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Tightening a deadly pore former

A small molecule was identified that binds to a unique site on the pro-apoptotic protein BAX, stabilizing the protein structure allosterically and preventing the conformational activation to a pore former by BH3 proteins.

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Fig. 1: A small molecule protein stabilizer prevents proapoptotic BAX pore formation in the mitochondrial membrane.


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Correspondence to Jialing Lin.

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Lin, J. Tightening a deadly pore former. Nat Chem Biol 15, 316–317 (2019).

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