PROTEIN UBIQUITYLATION

Decoding without the cipher

A new method introduces ubiquitin or ubiquitin-like proteins at specific sites in any protein without the requirement of the cellular ubiquitylation machinery. This will help decipher the code by which these modifications control cellular processes.

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Fig. 1: Modification of a target protein with ubiquitin or ubiquitin-like proteins.

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Correspondence to Andreas Matouschek.

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Competing interests

A.M. is a paid consultant for Kymera Therapeutics.

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Singh Gautam, A.K., Matouschek, A. Decoding without the cipher. Nat Chem Biol 15, 210–212 (2019). https://doi.org/10.1038/s41589-019-0230-9

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