Holliday junction resolvases lock dynamic DNA four-way junctions into specific structural conformations for symmetric DNA cleavage. Single-molecule studies now reveal that resolvases can relax their grip, enabling Holliday junction conformer transitions and branch migration in the enzyme-bound form.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Holliday, R. A. Genet. Res. 5, 282–304 (1964).
Wyatt, H. D. M. & West, S. C. Cold Spring Harb. Perspect. Biol. 6, a023192 (2014).
Zhou, R. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-018-0209-y (2018).
McKinney, S. A., Déclais, A.-C., Lilley, D. M. J. & Ha, T. Nat. Struct. Biol. 10, 93–97 (2003).
McKinney, S. A., Freeman, A. D. J., Lilley, D. M. J. & Ha, T. Proc. Natl Acad. Sci. USA 102, 5715–5720 (2005).
West, S. C. Annu. Rev. Genet. 31, 213–244 (1997).
Neelsen, K. J. & Lopes, M. Nat. Rev. Mol. Cell Biol. 16, 207–220 (2015).
Rass, U. Chromosoma 122, 499–515 (2013).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Rass, U. Freedom of movement. Nat Chem Biol 15, 209–210 (2019). https://doi.org/10.1038/s41589-019-0224-7
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41589-019-0224-7
