Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Fast bioelectrical switches

Faster-than-transcription control of cellular activities is an important but challenging engineering target. Using split ferredoxins and induced dimerization or conformational changes, newly developed metalloprotein switches provide a fast method to control electron flux.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: Metalloprotein switches for post-translational control of electron flow.


  1. 1.

    Cameron, D. E., Bashor, C. J. & Collins, J. J. Nat. Rev. Microbiol. 12, 381–390 (2014).

    CAS  Article  Google Scholar 

  2. 2.

    Taylor, N. D. et al. Nat. Methods 13, 177–183 (2016).

    CAS  Article  Google Scholar 

  3. 3.

    Rosenfeld, N., Elowitz, M. B. & Alon, U. J. Mol. Biol. 323, 785–793 (2002).

    CAS  Article  Google Scholar 

  4. 4.

    Atkinson, J. et al. Nat. Chem. Biol. (2019).

    Article  Google Scholar 

  5. 5.

    Stein, V. & Alexandrov, K. Trends Biotechnol. 33, 101–110 (2015).

    CAS  Article  Google Scholar 

  6. 6.

    Tantama, M. & Yellen, G. Methods Enzymol. 547, 355–371 (2014).

    CAS  Article  Google Scholar 

  7. 7.

    Hung, Y. P., Albeck, J. G., Tantama, M. & Yellen, G. Cell Metab. 14, 545–554 (2011).

    CAS  Article  Google Scholar 

  8. 8.

    TerAvest, M. A. & Ajo-Franklin, C. M. Biotechnol. Bioeng. 113, 687–697 (2016).

    CAS  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Michaela TerAvest.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

TerAvest, M. Fast bioelectrical switches. Nat Chem Biol 15, 99–100 (2019).

Download citation


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing