Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

PROTEIN ENGINEERING

Fast bioelectrical switches

Nature Chemical Biology volume 15, pages 99–100 (2019)Cite this article

Subjects

Faster-than-transcription control of cellular activities is an important but challenging engineering target. Using split ferredoxins and induced dimerization or conformational changes, newly developed metalloprotein switches provide a fast method to control electron flux.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Metalloprotein switches for post-translational control of electron flow.

References

  1. Cameron, D. E., Bashor, C. J. & Collins, J. J. Nat. Rev. Microbiol. 12, 381–390 (2014).

    Article  CAS  Google Scholar 

  2. Taylor, N. D. et al. Nat. Methods 13, 177–183 (2016).

    Article  CAS  Google Scholar 

  3. Rosenfeld, N., Elowitz, M. B. & Alon, U. J. Mol. Biol. 323, 785–793 (2002).

    Article  CAS  Google Scholar 

  4. Atkinson, J. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-018-0192-3 (2019).

    Article  Google Scholar 

  5. Stein, V. & Alexandrov, K. Trends Biotechnol. 33, 101–110 (2015).

    Article  CAS  Google Scholar 

  6. Tantama, M. & Yellen, G. Methods Enzymol. 547, 355–371 (2014).

    Article  CAS  Google Scholar 

  7. Hung, Y. P., Albeck, J. G., Tantama, M. & Yellen, G. Cell Metab. 14, 545–554 (2011).

    Article  CAS  Google Scholar 

  8. TerAvest, M. A. & Ajo-Franklin, C. M. Biotechnol. Bioeng. 113, 687–697 (2016).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA

    Michaela TerAvest

Authors
  1. Michaela TerAvest
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Michaela TerAvest.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

TerAvest, M. Fast bioelectrical switches. Nat Chem Biol 15, 99–100 (2019). https://doi.org/10.1038/s41589-018-0212-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41589-018-0212-3

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing