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Protein circuits reprogram cells

Two protein circuit systems, split-protease-cleavable orthogonal coiled-coil logic (SPOC logic) and circuits of hacked orthogonal modular proteases (CHOMP), have been developed to permit rapid and logic function-based control of mammalian cellular signaling.

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Fig. 1: Engineering protein circuit networks for cellular programming.


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Correspondence to Yingxiao Wang.

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Wu, Y., Wang, Y. Protein circuits reprogram cells. Nat Chem Biol 15, 96–97 (2019).

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