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SYNTHETIC BIOLOGY

Protein circuits reprogram cells

Nature Chemical Biology volume 15, pages 96–97 (2019)Cite this article

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Two protein circuit systems, split-protease-cleavable orthogonal coiled-coil logic (SPOC logic) and circuits of hacked orthogonal modular proteases (CHOMP), have been developed to permit rapid and logic function-based control of mammalian cellular signaling.

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Fig. 1: Engineering protein circuit networks for cellular programming.

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Authors and Affiliations

  1. Department of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA, USA

    Yiqian Wu & Yingxiao Wang

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  1. Yiqian Wu
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  2. Yingxiao Wang
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Correspondence to Yingxiao Wang.

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The authors declare no competing interests.

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Wu, Y., Wang, Y. Protein circuits reprogram cells. Nat Chem Biol 15, 96–97 (2019). https://doi.org/10.1038/s41589-018-0210-5

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