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Transcriptional kinases

Conducting the CTD orchestra

The carboxyl-terminal domain (CTD) of RNA polymerase II (Pol II) is post-translationally modified during gene expression. A recent study has identified a CTD kinase, Hrr25, that regulates the termination of noncoding RNA genes by recruiting Rtt103, a key termination factor.

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Fig. 1: CTD phosphorylation during transcription initiation, elongation and termination.

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Correspondence to Frédéric Coin.

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Genes Robles, C.M., Coin, F. Conducting the CTD orchestra. Nat Chem Biol 15, 97–98 (2019). https://doi.org/10.1038/s41589-018-0201-6

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