News & Views | Published:

Transcriptional kinases

Conducting the CTD orchestra

Nature Chemical Biologyvolume 15pages9798 (2019) | Download Citation

The carboxyl-terminal domain (CTD) of RNA polymerase II (Pol II) is post-translationally modified during gene expression. A recent study has identified a CTD kinase, Hrr25, that regulates the termination of noncoding RNA genes by recruiting Rtt103, a key termination factor.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Allison, L. A., Moyle, M., Shales, M. & Ingles, C. J. Cell 42, 599–610 (1985).

  2. 2.

    Corden, J. L., Cadena, D. L., Ahearn, J. M. Jr. & Dahmus, M. E. Proc. Natl Acad. Sci. USA 82, 7934–7938 (1985).

  3. 3.

    Harlen, K. M. & Churchman, L. S. Nat. Rev. Mol. Cell Biol. 18, 263–273 (2017).

  4. 4.

    Nemec, C. S. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-018-0194-1 (2018).

  5. 5.

    Buratowski, S. Mol. Cell 36, 541–546 (2009).

  6. 6.

    Nemec, C. M. et al. Proc. Natl Acad. Sci. USA 114, E3944–E3953 (2017).

  7. 7.

    Phatnani, H. P., Jones, J. C. & Greenleaf, A. L. Biochemistry 43, 15702–15719 (2004).

  8. 8.

    Bhatt, D. M. et al. Cell 150, 279–290 (2012).

  9. 9.

    Hintermair, C. et al. EMBO J. 31, 2784–2797 (2012).

Download references

Author information

Affiliations

  1. Department of Functional Genomics and Cancer, IGBMC, Illkirch Graffenstaden, France

    • Carlos Mario Genes Robles
    •  & Frédéric Coin

Authors

  1. Search for Carlos Mario Genes Robles in:

  2. Search for Frédéric Coin in:

Competing interests

The authors declare no competing interests.

Corresponding author

Correspondence to Frédéric Coin.

About this article

Publication history

Published

Issue Date

DOI

https://doi.org/10.1038/s41589-018-0201-6

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing