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Structures shed light on prostanoid signaling

Nature Chemical Biologyvolume 15pages35 (2019) | Download Citation

Prostanoids signal through G-protein-coupled receptors to regulate diverse physiological processes. Structures of three prostanoid receptors in inactive and active conformations now uncover the molecular determinants of ligand recognition and receptor activation and offer new opportunities for drug discovery.

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Author information

Affiliations

  1. Merck & Co., Inc., West Point, PA, USA

    • Kaspar Hollenstein

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Competing interests

The author declares no competing interests.

Corresponding author

Correspondence to Kaspar Hollenstein.

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DOI

https://doi.org/10.1038/s41589-018-0178-1

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