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GPCRs

Structures shed light on prostanoid signaling

Prostanoids signal through G-protein-coupled receptors to regulate diverse physiological processes. Structures of three prostanoid receptors in inactive and active conformations now uncover the molecular determinants of ligand recognition and receptor activation and offer new opportunities for drug discovery.

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Fig. 1: Prostanoid receptor agonists and antagonists.
Fig. 2: Receptor structure and ligand binding.

References

  1. Narumiya, S. Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. 83, 296–319 (2007).

    Article  CAS  Google Scholar 

  2. Toyoda, Y. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-018-0131-3 (2018).

    Article  PubMed  Google Scholar 

  3. Fan, H. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-018-0170-9 (2018).

  4. Morimoto, K. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-018-0171-8 (2018).

  5. Audet, M. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-018-0160-y (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Wang, L. et al. Mol. Cell 72, 48–59.e4 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Palczewski, K. et al. Science 289, 739–745 (2000).

    Article  CAS  PubMed  Google Scholar 

  8. Hanson, M. A. et al. Science 335, 851–855 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Srivastava, A. et al. Nature 513, 124–127 (2014).

    Article  CAS  PubMed  Google Scholar 

  10. Chrencik, J. E. et al. Cell 161, 1633–1643 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Hua, T. et al. Cell 167, 750–762.e14 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Ballesteros, J. A. & Weinstein, H. Methods Neurosci. 25, 366–428 (1995).

    Article  CAS  Google Scholar 

  13. Smit, M. J. et al. Annu. Rev. Pharmacol. Toxicol. 47, 53–87 (2007).

    Article  CAS  PubMed  Google Scholar 

Download references

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Correspondence to Kaspar Hollenstein.

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Hollenstein, K. Structures shed light on prostanoid signaling. Nat Chem Biol 15, 3–5 (2019). https://doi.org/10.1038/s41589-018-0178-1

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