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Expanding the terpenoid kingdom

Nature Chemical Biology volume 14, pages1069–1070(2018)Cite this article

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Terpenoids are assembled from five-carbon (C5) units, which limits the available scaffold chemical space for the discovery of bioactive molecules. A combination of enzyme and metabolic engineering now enables biosynthesis of a plethora of non-natural C11 terpenoids.

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Fig. 1: Establishing non-natural biosynthesis pathways for C11 terpenoid production in yeast.

References

  1. 1.

    Vickers, C. E., Williams, T. C., Peng, B. & Cherry, J. Curr. Opin. Chem. Biol. 40, 47–56 (2017).

    CAS  Article  Google Scholar 

  2. 2.

    Ignea, C. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-018-0166-5 (2018).

  3. 3.

    Nielsen, J. Science 349, 1050–1051 (2015).

    CAS  Article  Google Scholar 

  4. 4.

    Paddon, C. J. et al. Nature 496, 528–532 (2013).

    CAS  Article  Google Scholar 

  5. 5.

    Shen, B. Cell 163, 1297–1300 (2015).

    CAS  Article  Google Scholar 

  6. 6.

    Seki, H., Tamura, K. & Muranaka, T. Plant Cell Physiol. 56, 1463–1471 (2015).

    CAS  Article  Google Scholar 

  7. 7.

    Fischer, M. J., Meyer, S., Claudel, P., Bergdoll, M. & Karst, F. Biotechnol. Bioeng. 108, 1883–1892 (2011).

    CAS  Article  Google Scholar 

  8. 8.

    Ji, D. et al. J. Am. Chem. Soc. 133, 20857–20862 (2011).

    CAS  Article  Google Scholar 

  9. 9.

    Zhou, Y.J. et al. Nat. Energy 3, https://doi.org/10.1038/s41560-018-0197-x (2018).

    CAS  Article  Google Scholar 

  10. 10.

    Guo, J. et al. Proc. Natl Acad. Sci. USA 110, 12108–12113 (2013).

    CAS  Article  Google Scholar 

Download references

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  1. Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China

    Yongjin J. Zhou

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  1. Yongjin J. Zhou
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Correspondence to Yongjin J. Zhou.

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The author declares no competing interests.

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Zhou, Y.J. Expanding the terpenoid kingdom. Nat Chem Biol 14, 1069–1070 (2018). https://doi.org/10.1038/s41589-018-0167-4

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