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BIOSYNTHESIS

Expanding the terpenoid kingdom

Terpenoids are assembled from five-carbon (C5) units, which limits the available scaffold chemical space for the discovery of bioactive molecules. A combination of enzyme and metabolic engineering now enables biosynthesis of a plethora of non-natural C11 terpenoids.

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Fig. 1: Establishing non-natural biosynthesis pathways for C11 terpenoid production in yeast.

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Correspondence to Yongjin J. Zhou.

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Zhou, Y.J. Expanding the terpenoid kingdom. Nat Chem Biol 14, 1069–1070 (2018). https://doi.org/10.1038/s41589-018-0167-4

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