Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

GLYCOSYLTRANSFERASES

Divining sugar substrates

Scientists have combined functional and computational analysis to predict the substrate specificity of a family of glycosyltransferases from Arabidopsis thaliana, creating a tool that enables researchers to classify the donor and acceptor specificity of glycosyltransferase enzymes.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Combined functional and computational analysis to predict glycosyltransferase specificity in one tool based on an exemplarily structure.

References

  1. Lairson, L. L., Henrissat, B., Davies, G. J. & Withers, S. G. Annu. Rev. Biochem. 77, 521–555 (2008).

    Article  CAS  Google Scholar 

  2. Gantt, R. W., Peltier-Pain, P., Singh, S., Zhou, M. & Thorson, J. S. Proc. Natl. Acad. Sci. USA 110, 7648–7653 (2013).

    Article  CAS  Google Scholar 

  3. Coutinho, P. M., Deleury, E., Davies, G. J. & Henrissat, B. J. Mol. Biol. 328, 307–317 (2003).

    Article  CAS  Google Scholar 

  4. Yang, M. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-018-0154-9 (2018).

  5. Lombard, V., Golaconda Ramulu, H., Drula, E., Coutinho, P. M. & Henrissat, B. Nucleic Acids Res. 42, D490–D495 (2014).

    Article  CAS  Google Scholar 

  6. Gloster, T. M. Curr. Opin. Struct. Biol. 28, 131–141 (2014).

    Article  CAS  Google Scholar 

  7. Lim, E.-K. Glycobiology 13, 139–145 (2003).

    Article  CAS  Google Scholar 

  8. Sánchez-Rodríguez, A. et al. BMC Genomics 15, 349 (2014).

    Article  Google Scholar 

  9. Schmid, J., Heider, D., Wendel, N. J., Sperl, N. & Sieber, V. Front. Microbiol. 7, 182 (2016).

    PubMed  PubMed Central  Google Scholar 

  10. George Thompson, A. M., Iancu, C. V., Neet, K. E., Dean, J. V. & Choe, J. Y. Sci. Rep. 7, 46629 (2017).

    Article  Google Scholar 

  11. Moreland, J. L., Gramada, A., Buzko, O. V., Zhang, Q. & Bourne, P. E. BMC Bioinformatics 6, 21 (2005).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jochen Schmid.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Schmid, J. Divining sugar substrates. Nat Chem Biol 14, 1071–1072 (2018). https://doi.org/10.1038/s41589-018-0165-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41589-018-0165-6

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing