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The substrate lends a hand

Duramycin is a small post-translationally modified peptide with antibody-like affinity for phosphatidylethanolamine. As it turns out, the same functionality that is essential for duramycin activity helps to catalyze the formation of its conformationally constrained and compact polycyclic architecture.

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Fig. 1: Structure and mechanism of DurN-catalyzed lysinoalanine formation.


  1. Arnison, P. G. et al. Nat. Prod. Rep. 30, 108–160 (2013).

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  2. An, L. et al. Nat. Chem. Biol. (2018).

  3. Makino, A. et al. J. Biol. Chem. 278, 3204–3209 (2003).

    Article  CAS  PubMed  Google Scholar 

  4. Hosoda, K. et al. J. Biochem. 119, 226–230 (1996).

    Article  CAS  PubMed  Google Scholar 

  5. Ökesli, A., Cooper, L. E., Fogle, E. J. & van der Donk, W. A. J. Am. Chem. Soc. 133, 13753–13760 (2011).

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  6. Dall’Acqua, W. & Carter, P. Protein Sci. 9, 1–9 (2000).

    Article  PubMed Central  PubMed  Google Scholar 

  7. Carter, P. & Wells, J. A. Science 237, 394–399 (1987).

    Article  CAS  PubMed  Google Scholar 

Download references

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Correspondence to Albert A. Bowers.

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Bowers, A.A. The substrate lends a hand. Nat Chem Biol 14, 907–908 (2018).

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