Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


The substrate lends a hand

Duramycin is a small post-translationally modified peptide with antibody-like affinity for phosphatidylethanolamine. As it turns out, the same functionality that is essential for duramycin activity helps to catalyze the formation of its conformationally constrained and compact polycyclic architecture.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: Structure and mechanism of DurN-catalyzed lysinoalanine formation.


  1. 1.

    Arnison, P. G. et al. Nat. Prod. Rep. 30, 108–160 (2013).

    CAS  Article  PubMed Central  PubMed  Google Scholar 

  2. 2.

    An, L. et al. Nat. Chem. Biol. (2018).

  3. 3.

    Makino, A. et al. J. Biol. Chem. 278, 3204–3209 (2003).

    CAS  Article  PubMed Central  PubMed  Google Scholar 

  4. 4.

    Hosoda, K. et al. J. Biochem. 119, 226–230 (1996).

    CAS  Article  PubMed Central  PubMed  Google Scholar 

  5. 5.

    Ökesli, A., Cooper, L. E., Fogle, E. J. & van der Donk, W. A. J. Am. Chem. Soc. 133, 13753–13760 (2011).

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  6. 6.

    Dall’Acqua, W. & Carter, P. Protein Sci. 9, 1–9 (2000).

    Article  PubMed Central  PubMed  Google Scholar 

  7. 7.

    Carter, P. & Wells, J. A. Science 237, 394–399 (1987).

    CAS  Article  PubMed Central  PubMed  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Albert A. Bowers.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Bowers, A.A. The substrate lends a hand. Nat Chem Biol 14, 907–908 (2018).

Download citation


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing