Duramycin is a small post-translationally modified peptide with antibody-like affinity for phosphatidylethanolamine. As it turns out, the same functionality that is essential for duramycin activity helps to catalyze the formation of its conformationally constrained and compact polycyclic architecture.
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Bowers, A.A. The substrate lends a hand. Nat Chem Biol 14, 907–908 (2018). https://doi.org/10.1038/s41589-018-0135-z
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DOI: https://doi.org/10.1038/s41589-018-0135-z